Anti-IL1 beta antibody GTX74034 from GeneTex

Product Specs
ItemAnti-IL1 beta antibody
CompanyGeneTex
Price Pricing Info Supplier Page
Catalog NumberGTX74034
Quantity100 µl
ApplicationsWB, ICC/IF, IHC-P, IHC-Fr, ELISA, IHC
Conjugate/TagUnconjugated
PurityPurified by antigen-affinity chromatography
ReactivityHuman, Mouse, Rat
TargetIL1 beta
IsotypeIgG
HostRabbit
Antibody TypePrimary Antibodies
ImmunogenRecombinant murine IL1 beta
NCBI Full Gene Nameinterleukin 1 beta
NCBI Gene Aliasesinterleukin 1 beta, IL-1beta, Il-1b, IL-1beta, Il-1b
ClonalityPolyclonal
Concentration1mg/ml
FormatPBS, no preservative
Research AreaCell Biology, Neuroscience, Metabolism, Immunology, Cardiovascular
Gene NameIl1b
Molecular Weight31

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GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammagingbioRxivDecember 4, 2023Mitsunori Nomura, Natalia Faraj Murad, Sidharth S Madhavan, Brenda Eap, Thelma Y Garcia, Carlos Galicia Aguirre, Eric Verdin, Lisa Ellerby, David Furman, John C Newman610419, BD Biosciences; anti-Kac: #9441, Cell Signaling; anti-Kbhb: PTM-1201, PTM-Biolabs; anti-IL-1β: GTX74034, GeneTex; anti-mouse IgG: #7076, Cell Signaling; anti-rabbit IgG: #7074, Cell Signaling. IL-1β ELISA IL-1β

(2) The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in miceFrontiers in ImmunologyNovember 28, 2023Elien Eeckhout, Tomoko Asaoka, Hanne Van Gorp, Dieter Demon, Charlotte Girard-Guyonvarc’h, Vanessa Andries, Lars Vereecke, Cem Gabay, Mohamed Lamkanfi, Geert van Loo, et al.primary antibodies against caspase-1 (1:1000; Adipogen, AG-20B-0042-C100), IL-1β (1:2000; GeneTex, GTX74034), GSDMD (1:1000, Abcam, ab209845) and IL-18 (1:1000, Biovision, 5180R-100). After washing, membranes

(3) Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesityJournal of Clinical InvestigationOctober 2, 2023Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, et al.p-HSL (S563) (1:1,000; 4139, Cell Signaling), HSL (1:1,000; 4107, Cell Signaling), IL-1β (1:1,000; GTX74034, Genetex), p-JNK (1:1,000; 4668S, Cell Signaling), JNK (1:1,000; 9252S, Cell Signaling), p-p38 MAPK

(4) Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infectionMicrobiological ResearchOctober 1, 2023Ankit Pandeya, Yan Zhang, Jian Cui, Ling Yang, Jeffery Li, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan WeiCat#AG-20B-0042) at 1:1000 dilution. Pro-IL-1β and IL-1β (p17) were detected using anti-IL-1β (GeneTex Cat#GTX74034) at 1:1000 dilution. Blots were imaged using the BIO-RAD ChemiDoc MP imaging system as well as the Azure

(5) Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammationbioRxivSeptember 3, 2023Jian Cui, Hua Li, Guoying Zhang, Yan Zhang, Ling Yang, Martha M.S. Sim, Jeremy P. Wood, Yinan Wei, Zhenyu Li, Congqing Wu(Adipogen, Cat#AG-20B-0042-C100) at 1:1000 dilution. IL-1β was detected using anti-IL-1β (GeneTex, Cat#GTX74034) at 1:1000 dilution. GSDMD was detected using anti-GSDMD (Abcam, Cat#ab219800) at 1:1000 dilution. NINJ1

(6) Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerveFrontiers in NeuroscienceJune 29, 2023Szu-Han Chen, Chia-Ching Wu, Wan-Ling Tseng, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Sheng-Che Lin, Yuan-Yu Hsueh1:200), CD68 (ab125212, 1:200), and TNF-α (ab205587, 1:200) from Abcam, Cambridge, MA, USA; and IL-1β (GTX74034, 1:200) and IB4 (GTX54372) from GeneTex, Irvine, CA, USA. The tissue was embedded in OCT (Tissue-Tek®,

(7) RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injuryCell death & diseaseJune 21, 2023Liu PY, Chen CY, Lin YL, Lin CM, Tsai WC, Tsai YL, Lin GJ, Chen YG, Wang SY, Sun RN, et al.(21865-1-AP; Proteintech, USA), anti-IL-6 (E-AB-70050; Elabscience, Houston, TX, USA), anti-IL-1β (GTX74034; GeneTex, Alton Pkwy Irvine, CA, USA) and anti-RNF128 (The RNF128 antibody is made in our laboratory). In

(8) Activation of Inflammasome during Bluetongue Virus InfectionPathogensJune 4, 2023Marie Pourcelot, Rayane Amaral da Silva Moraes, Sandrine Lacour, Aurore Fablet, Grégory Caignard, Damien Vitouranti-NLRP3 (Cryo-2) (Adipogen, #AG-20B-0014, 1/1000), rabbit anti-IL-1β (Genetex, Irvine, CA, USA, # GTX74034, 1/1000), and rabbit anti-bovine IL-1β (KingFisher Biotech, St Paul, MN, USA, # KP1109B-100, 1/1000). 5.

(9) Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infectionCell death & diseaseApril 21, 2023Eeckhout E, Hamerlinck L, Jonckheere V, Van Damme P, van Loo G, Wullaert A.primary antibodies against caspase-1 (1:1000; Adipogen, AG-20B-0042-C100), IL-1β (1:2000; GeneTex, GTX74034), GSDMD (1:1000, Abcam, ab209845), anti-cCasp3 Asp175 (1:1000, Cell Signaling, 9661S), caspase-3 (1:1000,

(10) Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammationThe Journal of biological chemistryMarch 1, 2023Goldberg EL, Letian A, Dlugos T, Leveau C, Dixit VD.assay (Bio-Rad) and equal amounts of total protein were analyzed. Antibodies used were IL-1β (GeneTex # GTX74034), HMGCL (Proteintech # 16898-1-AP), Kbhb (PTM Biosciences #PTM-1201RM), and β-actin (Cell Signaling

(11) Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signalingNeuroreportFebruary 1, 2023Xia M, Chen YJ, Chen B, Ru X, Wang J, Lin J, Tang X, Chen W, Hu R, Li W, et al.Massachusetts, USA; Cat: 17198), rabbit anti-IL-1β (1:1000; GeneTex, San Antonio, Texas, USA; Cat: GTX74034), rabbit anti-extracellular regulated protein kinase (ERK) (1:1000, Cambridge, UK; Abcam; Cat: ab17942),

(12) Protocol to purify recombinant inflammatory caspases and assess their catalytic activity in vitroSTAR protocolsDecember 16, 2022Devant P, Kagan JC.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Rabbit polyclonal anti-pro-IL-1β,Genetex,GTX74034 HRP-conjugated goat anti-rabbit IgG (H+L),Jackson Immunolabs,111-035003 ,, Bacterial and virus strains,Bacterial

(13) Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell deatheLifeDecember 5, 2022Borges JP, Sætra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, et al.ab209845; RRID: #AB_2783550), Caspase-1 (Adipogen AG-20B-0042-C100; RRID: #AB_2755041), pro-IL-1β (Genetex GTX74034; RRID: #AB_378141), and actin (Sigma A5441; RRID: #AB_476744). Mitochondrial membrane potential and

(14) Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant MelanomaMolecular Cancer ResearchDecember 2, 2022Megane Vernon, Nicole A. Wilski, Daniel Kotas, Weijia Cai, Danielle Pomante, Manoela Tiago, Emad S. Alnemri, Andrew E. AplinCat# sc-73614, RRID:AB_1131294), GSDME (Abcam Cat# ab215191, RRID:AB_2737000), IL-1β (GeneTex Cat# GTX74034, RRID:AB_378141), and Actin (Sigma-Aldrich Cat# A2066, RRID:AB_476693). Secondary antibodies used were

(15) Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentationCell reportsAugust 16, 2022Gros M, Segura E, Rookhuizen DC, Baudon B, Heurtebise-Chrétien S, Burgdorf N, Maurin M, Kapp EA, Simpson RJ, Kozik P, et al.anti-cleaved Parp (#9544, Cell Signaling Technologies), anti-Gasdermin-D (Genentech), anti-IL-1β (#GTX74034, Genetex), anti MLKL (#MABC604, Millipore (reducing conditions) or #SAB1302339, Sigma-Aldrich (non-reducing

(16) Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosisJournal of neuroinflammationJune 10, 2022Ding R, Li H, Liu Y, Ou W, Zhang X, Chai H, Huang X, Yang W, Wang Q.

(17) Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosisProceedings of the National Academy of Sciences of the United States of AmericaMay 24, 2022Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, et al.were then transferred to blocking solution containing the primary antibody against IL-1β (GeneTex, GTX74034) and incubated overnight at 4 °C. After that, sections were washed with PBS 3X for 15 min each. Then,

(18) Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cellsScientific reportsMarch 7, 2022Lee SH, Choi MR, Chung J, Choi SH, Park SK, Kim YM.

(19) Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosisProceedings of the National Academy of Sciences of the United States of AmericaNovember 23, 2021Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, et al.

(20) Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathwaysAgingSeptember 24, 2021Lee KT, Chen BC, Liu SC, Lin YY, Tsai CH, Ko CY, Tang CH, Tung KC.management of OA disease. MATERIALS AND METHODS Materials Nesfatin-1 (GTX00739, polyclonal), IL-1β (GTX74034, polyclonal), β-actin (GTX109639, polyclonal), p85 (GTX111068, polyclonal), Akt (GTX121937, polyclonal),

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Anti-IL1 beta antibody

Anti-IL1 beta antibody from GeneTex

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Anti-IL1 beta antibody from GeneTex

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